The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Apr. 28, 2014
Applicant:
Vanderbilt University, Nashville, TN (US);
Inventors:
Craig W. Lindsley, Brentwood, TN (US);
P. Jeffrey Conn, Nashville, TN (US);
Shaun R. Stauffer, Brentwood, TN (US);
Joseph David Panarese, Nashville, TN (US);
Assignee:
Vanderbilt University, Nashville, TN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/498 (2006.01); C07D 241/44 (2006.01); C07D 403/10 (2006.01); A61K 9/00 (2006.01); A61K 47/36 (2006.01); A61K 9/10 (2006.01); A61K 9/20 (2006.01);
U.S. Cl.
CPC ...
C07D 403/10 (2013.01); A61K 9/0019 (2013.01); A61K 9/10 (2013.01); A61K 9/2018 (2013.01); A61K 47/36 (2013.01);
Abstract
The invention relates to substituted 1-benzylquinoxalin-2(1H)-one analogs, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M(mAChR M); methods for making the compounds; pharmaceutical compositions; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. Exemplary 1-benzylquinoxalin-2(1H)-one compounds include compounds of the following formula: