The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Feb. 09, 2016
Applicant:
Arrowhead Research Corporation, Pasadena, CA (US);
Inventor:
Jon E. Chatterton, Aliso Viejo, CA (US);
Assignee:
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); A61K 47/48 (2006.01); A61K 31/7088 (2006.01); C12N 15/11 (2006.01); A61K 31/713 (2006.01); A61K 38/16 (2006.01); C12N 15/113 (2010.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48561 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 38/16 (2013.01); A61K 47/484 (2013.01); A61K 47/48246 (2013.01); A61K 47/48276 (2013.01); A61K 47/48323 (2013.01); C07K 16/28 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/1138 (2013.01); C12N 2310/14 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3513 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/30 (2013.01); C12N 2320/32 (2013.01); C12N 2320/35 (2013.01);
Abstract
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.