The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Jun. 04, 2012
Hyun Su Bae, Seoul, KR;
Hyo Jung Lee, Incheon, KR;
Gi Hyun Lee, Seoul, KR;
Hyun Seong Kim, Busan, KR;
Soo Jin Park, Daegu, KR;
Eun Sook Chung, Gyeonggi-do, KR;
Tae Won Choi, Seoul, KR;
Hyun Su Bae, Seoul, KR;
Hyo Jung Lee, Incheon, KR;
Gi Hyun Lee, Seoul, KR;
Hyun Seong Kim, Busan, KR;
Soo Jin Park, Daegu, KR;
Eun Sook Chung, Gyeonggi-do, KR;
Tae Won Choi, Seoul, KR;
UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, Gyeonggi-do, KR;
Abstract
The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity comprising a polypeptide comprising a bee venom-PLA2 amino acid sequence exclusive of a leader sequence as an active ingredient. The secretory bee venom-phospholipase A2 of the present invention activates a regulatory T cell and suppress a differentiation of Th1/Th7. Therefore, the present polypeptide can be used as a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity, i.e. autoimmune diseases, allergic diseases, or neurodegenerative diseases.