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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9526731 B1

PDFFull Text
Date of Patent:
Dec. 27, 2016

Filed:

Dec. 08, 2014

Method of inhibiting c-kit kinase

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Carl R. Illig, Phoenixville, PA (US);

Shelley K. Ballentine, Lansdale, PA (US);

Jinsheng Chen, Exton, PA (US);

Sanath K. Meegalla, Garnet, NJ (US);

M. Jonathan Rudolph, Doylestown, PA (US);

Mark J. Wall, Lansdale, PA (US);

Kenneth J. Wilson, Playas Del Coco, CR;

Renee Louise Desjarlais, Saint Davids, PA (US);

Carl M. Manthey, Chester Springs, PA (US);

Christopher J. Molloy, Yardley, PA (US);

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:
Primary Examiner:

Craig Ricci

Int. Cl.
CPC ...
A61K 31/41 (2006.01); A61K 31/435 (2006.01); A61K 31/5377 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 45/06 (2006.01); A61N 5/10 (2006.01); C07D 401/12 (2006.01); C12N 9/99 (2006.01); A61K 31/4178 (2006.01); C07D 307/68 (2006.01); C07D 401/14 (2006.01); C07D 407/12 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/4178 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); C07D 307/68 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C12N 9/99 (2013.01); A61N 2005/1098 (2013.01);
Abstract

A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to C-KIT using a compound of the present invention: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders.

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