The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 2016

Filed:

Aug. 19, 2013
Applicant:

The Broad Institute, Inc., Cambridge, MA (US);

Inventors:

Marek Maria Nagiec, Medford, MA (US);

Jose R. Perez, Salem, CT (US);

Michelle Palmer, Harvard, MA (US);

Adam Skepner, Woburn, MA (US);

Eamon Comer, Watertown, MA (US);

Assignee:

The Broad Institute, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4725 (2006.01); C07D 401/06 (2006.01); C07D 493/04 (2006.01); C07D 498/04 (2006.01); C07D 305/08 (2006.01); A61K 31/35 (2006.01); A61K 31/381 (2006.01); A61K 31/4025 (2006.01); A61K 31/422 (2006.01); A61K 45/06 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4725 (2013.01); A61K 31/35 (2013.01); A61K 31/381 (2013.01); A61K 31/4025 (2013.01); A61K 31/422 (2013.01); A61K 45/06 (2013.01); C07D 305/08 (2013.01); C07D 401/06 (2013.01); C07D 493/04 (2013.01); C07D 498/04 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The present invention relates to compounds that are useful for modulating hepatic cholesterol metabolism in an animal. The invention includes methods of making and using the compounds of the invention. The invention further provides methods of treating, preventing and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in an animal, such as a human, comprising administering compounds of the invention, or pharmaceutically acceptable salts or solvates thereof, to the animal.


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