The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2016
Filed:
Oct. 22, 2010
Applicants:
Neil Cashman, Vancouver, CA;
Marty Lehto, Burlington, CA;
Inventors:
Neil Cashman, Vancouver, CA;
Marty Lehto, Burlington, CA;
Assignee:
PROMIS NEUROSCIENCES Inc., Toronto, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 49/00 (2006.01); A61K 49/16 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01); G01N 33/53 (2006.01); G01N 33/567 (2006.01); A61B 5/00 (2006.01); G01N 33/68 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); G01N 33/58 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6896 (2013.01); C07K 16/18 (2013.01); C07K 16/40 (2013.01); G01N 33/581 (2013.01); G01N 33/68 (2013.01); G01N 33/6845 (2013.01); A61K 38/00 (2013.01); G01N 2333/90283 (2013.01); G01N 2800/2828 (2013.01);
Abstract
The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent is used to detect protein with target epitope that was inaccessible during contact with the blocking agent.