The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2016
Filed:
Jul. 11, 2005
Katrin Eppelmann, Kalamazoo, MI (US);
Petrus M. M. Nossin, Nederweert, NL;
Susanne M. Kremer, Linnich-Gereonsweiler, DE;
Marcel G. Wubbolts, Sittard, NL;
Katrin Eppelmann, Kalamazoo, MI (US);
Petrus M. M. Nossin, Nederweert, NL;
Susanne M. Kremer, Linnich-Gereonsweiler, DE;
Marcel G. Wubbolts, Sittard, NL;
DSM IP ASSETS B.V., Heerlen, NL;
Abstract
Process for biochemical synthesis of 1,4-butanediannine in a microorganism having an increased level of an ornithine decarboxylase activity as compared to the native level of the ornithine decarboxylase activity, in which the increased ornithine decarboxylase activity is obtained by overexpression of an ornithine decarboxylase encoding gene with increased translational and/or transcriptional efficiency. The process is performed by excreting 1,4-butanediamine produced in the microorganism into a fermentation broth, and recovering the 1,4-butanediannine from the fermentation broth. The increased translational and/or transcriptional efficiency is obtained by the use of a strong, regulated promoter consisting of an isopropvl-B-D-thiogalactoside (IPTG) inducible strong promoter.