The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2016
Filed:
Apr. 28, 2015
Applicant:
The Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Assignee:
The Board of Regents of the University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 5/071 (2010.01); A61P 9/00 (2006.01); C12N 5/077 (2010.01); C07K 14/47 (2006.01); A61K 31/7105 (2006.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); A61K 31/7105 (2013.01); A61K 38/17 (2013.01); A61K 45/06 (2013.01); C07K 14/4702 (2013.01); A61K 38/00 (2013.01); C12N 2501/40 (2013.01); C12N 2770/00043 (2013.01);
Abstract
The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.