The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2016
Filed:
Aug. 29, 2013
Alectos Therapeutics Inc., Burnaby, CA;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Ernest J. McEachern, Vancouver, CA;
David J. Vocadlo, Burnaby, CA;
Yuanxi Zhou, Burnaby, CA;
Harold G. Selnick, West Point, PA (US);
Alectos Therapeutics Inc., Burnaby, CA;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The invention provides compounds of Formula (I) for inhibiting gh cosidases, prodrugs of the compounds, and pharmaceutical compositions comprising the compounds or prodrugs of the compounds. The invention also provides method of treating diseases and disorders related to deficiency or over-expression of O-gh coprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase), accumulation or deficiency of 2-acetamido-2-deoxy-β-D-glucopyranoside (O-GlcNAc).