The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2016
Filed:
Dec. 11, 2013
Epitech Group S.r.l., Milan, IT;
Antonio Calignano, Milan, IT;
Giuseppe D'Agostino, Milan, IT;
Sonia Laneri, Milan, IT;
Rosaria Meli, Milan, IT;
Carmine Ostacolo, Milan, IT;
Roberto Russo, Milan, IT;
Antonia Sacchi, Milan, IT;
Diana Tronino, Milan, IT;
Francesco Della Valle, Milan, IT;
Maria Federica Della Valle, Milan, IT;
Gabriele Marcolongo, Milan, IT;
EPITECH GROUP S.r.l., Milan, IT;
Abstract
The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.