The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2016
Filed:
Dec. 14, 2011
Applicants:
Stephan Von Gunten, Bern, CH;
Marc Wehrli, Bern, CH;
Adrian Zürcher, Bern, CH;
Sylvia Miescher, Bern, CH;
Inventors:
Stephan Von Gunten, Bern, CH;
Marc Wehrli, Bern, CH;
Adrian Zürcher, Bern, CH;
Sylvia Miescher, Bern, CH;
Assignees:
CSL BEHRING AG, Bern, CH;
UNIVERSITAT BERN, Bern, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); C07K 16/283 (2013.01); C07K 2317/73 (2013.01); C07K 2317/75 (2013.01);
Abstract
The invention relates to the use of CD89 activating molecules, in particular Fc alpha comprising molecules, and more particularly, IgA, for inducing apoptosis in neutrophils. Anti-CD89 antibodies can alternatively be used. The CD89 activation is beneficial in the treatment of various disorders associated with increases in neutrophils, such as autoimmune disorders, inflammatory disorders, NETosis, or cystic fibrosis.