The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2016
Filed:
Mar. 30, 2012
Applicants:
Jan Johansson, Stockholm, SE;
Jenny Presto, Uppsala, SE;
Inventors:
Jan Johansson, Stockholm, SE;
Jenny Presto, Uppsala, SE;
Assignee:
ALPHABETA AB, Djursholm, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); G01N 33/567 (2006.01); A61K 38/00 (2006.01); A61K 49/00 (2006.01); A61K 38/17 (2006.01); G01N 33/68 (2006.01); C07K 14/47 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1709 (2013.01); C07K 14/47 (2013.01); G01N 33/5058 (2013.01); G01N 33/6896 (2013.01); A61K 38/00 (2013.01); G01N 2500/02 (2013.01); G01N 2800/12 (2013.01); G01N 2800/2821 (2013.01);
Abstract
A method involves screening a candidate compound for activity in the treatment of a condition associated with formation of amyloid protein fibrils in a mammal, such as Alzheimer's disease. It is determined whether the trimer/monomer ratio of a chaperone protein is decreased in the presence of the candidate compound. The chaperone protein is or has a high identity to the Brichos domains of Bri2, Bri3 or proSP-C from human. Monomers of the chaperone proteins and/or compounds that promote formation of these monomers are useful for medical treatment of the condition.