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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9522140 B1

PDFFull Text
Date of Patent:
Dec. 20, 2016

Filed:

Jul. 02, 2015

Aryl substituted carboxamide derivatives as calcium or sodium channel blockers

Applicant:

Raqualia Pharma Inc., Aichi, JP;

Inventors:

Tadashi Inoue, Aichi, JP;

Shuzo Watanabe, Aichi, JP;

Tatsuya Yamagishi, Aichi, JP;

Yoshimasa Arano, Aichi, JP;

Mikio Morita, Aichi, JP;

Kaoru Shimada, Aichi, JP;

Assignee:

RAQUALIA PHARMA INC., Aichi, JP;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Jennifer M Kim

Int. Cl.
CPC ...
C07D 405/12 (2006.01); C07D 213/65 (2006.01); C07D 401/12 (2006.01); A61K 31/44 (2006.01); A61K 31/444 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/4706 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); C07D 215/40 (2006.01); C07D 241/18 (2006.01); C07D 401/14 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/44 (2013.01); A61K 31/443 (2013.01); A61K 31/444 (2013.01); A61K 31/4433 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/4706 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); C07D 213/65 (2013.01); C07D 215/40 (2013.01); C07D 241/18 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract

The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blocker such as Naand Na, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.

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