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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9518976 B1

PDFFull Text
Expired
Date of Patent:
Dec. 13, 2016

Filed:

Sep. 13, 2007

Methods for identifying or assaying for agents that increase beta-cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decrease fat mass

Applicants:

Gerard Karsenty, New York, NY (US);

Patricia F. Ducy, New York, NY (US);

Inventors:

Gerard Karsenty, New York, NY (US);

Patricia F. Ducy, New York, NY (US);

Assignee:

The Trustees of Columbia University in The City of New York, New York, NY (US);

Attorney:

Andrews Kurth Kenyon LLP

Primary Examiner:

Reza Ghafoorian

Int. Cl.
CPC ...
C12P 21/06 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5008 (2013.01); G01N 33/5088 (2013.01); G01N 2333/78 (2013.01); G01N 2333/916 (2013.01); G01N 2333/988 (2013.01);
Abstract

The present invention is directed to cell-based and non-cell based methods of drug screening to identify agents, or assay agents, that reduce OST-PTP or gamma-carboxylase activity or expression, or increase the level of undercarboxylated osteocalcin or adiponectin activity or expression. Such agents find use in treating or preventing a disorder related to the OST-PTP signaling pathway. Such disorders include, metabolic syndrome, glucose intolerance, type 1 or type 2 diabetes, atherosclerosis, or obesity. Such agents may be used to treat disorders characterized by decreased insulin production, deceased insulin sensitivity, and decreased glucose tolerance or increased fat mass.

Find Patent Forward Citations

Karsenty, Gerard. (2016). Methods for identifying or assaying for agents that increase beta-cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decrease fat mass (U.S. Patent No. 9518976). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9518976

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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