The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2016
Filed:
Aug. 21, 2013
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Kang Li, Beijing, CN;
Bin-Bing Stephen Zhou, Shanghai, CN;
Wenjuan Wu, Houston, TX (US);
Sek Chung Fung, Gaithersburg, MD (US);
Sanjaya Singh, Sandy Hook, CT (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/30 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); G01N 33/68 (2006.01); G01N 33/574 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); C07K 16/00 (2013.01); C07K 16/28 (2013.01); G01N 33/57492 (2013.01); G01N 33/6893 (2013.01); A61K 39/00 (2013.01); A61K 39/39558 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5152 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/75 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.