The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2016
Filed:
Oct. 16, 2014
Applicant:
Procos S.p.a., Cameri, IT;
Inventors:
Tommaso Angelini, Oleggio, IT;
Piergiorgio Bettoni, Casale Monferrato, IT;
Jacopo Roletto, Turin, IT;
Paolo Paissoni, Druento, IT;
Assignee:
PROCOS S.P.A., Cameri (NO), IT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01);
Abstract
Disclosed is a process for the industrial synthesis of Lurasidone from (1R,2R)-cyclohexane-1,2-diyldimethanol (1), 3-(piperazin-1-yl)benzo[d]isothiazole (3) and (3aR,4R,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1,3-dione (6).). Said process is optimised to obtain Lurasidone with high yields and high purities by preparing highly pure synthesis intermediates, using critical raw materials and reagents in amounts close to the stoichiometric amounts, increasing productivity and reducing the costs and environmental impact of the process.