The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2016
Filed:
Feb. 27, 2015
Applicant:
Mirna Therapeutics, Inc., Austin, TX (US);
Inventors:
Andreas Bader, Austin, TX (US);
Jane Zhao, Austin, TX (US);
Assignee:
MIRNA THERAPEUTICS, INC., Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 35/00 (2006.01); A61K 31/713 (2006.01); A61K 31/44 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 31/44 (2013.01); C12N 15/113 (2013.01); C12N 2320/31 (2013.01);
Abstract
A method of treating a subject having liver cancer can include administering a synthetic oligonucleotide to a subject having liver cancer, the oligonucleotide comprising a sequence that is at least 80% identical to at least one of SEQ ID NO:1-12 (e.g., a miR-34 or miR-215 mimic); and administering sorafenib to the subject, wherein the molar ratio of sorafenib:oligonucleotide administered to the subject is in the range of about 10-2000 (e.g., a ratio that provides a superior, for example synergistic or greater than additive, effect).