The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 13, 2016

Filed:

Mar. 14, 2016
Applicant:

Massachusetts Eye and Ear Infirmary, Boston, MA (US);

Inventor:

Benjamin S. Bleier, Weston, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61F 13/00 (2006.01); A61F 2/00 (2006.01); A61K 9/14 (2006.01); A61K 38/00 (2006.01); A61N 1/30 (2006.01); A61M 31/00 (2006.01); A61M 37/00 (2006.01); A61F 2/02 (2006.01); A61F 2/28 (2006.01); A61K 9/00 (2006.01); A61K 31/137 (2006.01); A61K 31/485 (2006.01); A61K 31/473 (2006.01); A61K 38/18 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0085 (2013.01); A61K 31/137 (2013.01); A61K 31/473 (2013.01); A61K 31/485 (2013.01); A61K 38/18 (2013.01); A61K 38/185 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); A61M 31/00 (2013.01);
Abstract

Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject.


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