The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2016
Filed:
Aug. 02, 2011
Lynn Macdonald, Harrison, NY (US);
Sean Stevens, Del Mar, CA (US);
Cagan Gurer, Chappaqua, NY (US);
Karolina A. Hosiawa, Yorktown Heights, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Lynn Macdonald, Harrison, NY (US);
Sean Stevens, Del Mar, CA (US);
Cagan Gurer, Chappaqua, NY (US);
Karolina A. Hosiawa, Yorktown Heights, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided.