The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 06, 2016

Filed:

May. 03, 2013
Applicants:

Boreal Genomics Corp., Mountain View, CA (US);

The University of British Columbia, Vancouver, CA;

Inventors:

Andrea Marziali, North Vancouver, CA;

Matthew Wiggin, Vancouver, CA;

Gosuke Shibahara, Vancouver, CA;

Valentina S. Vysotskaia, Belmont, CA (US);

Assignees:

Boreal Genomics Inc., Vancouver, British Columbia, unknown;

The University of British Columbia, Vancouver, British Columbia, unknown;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6816 (2013.01);
Abstract

The invention discloses methods and apparatus for characterizing trace nucleic acids that are biomarkers for disease. The methods and apparatus provide increased sensitivity to such trace nucleic acids, and allow analysis of nucleic acids present in a sample at only 0.01% of the wild-type sequences. The methods and apparatus are also designed for straightforward multiplexing, thus allowing pooling of clinical samples.


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