The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
Oct. 03, 2014
Method for rapidly evaluating performance of short interfering rna with novel chemical modifications
Applicant:
Sirna Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Gabor Butora, Rahway, NJ (US);
Ian W. Davies, Kenilworth, NJ (US);
William Michael Flanagan, Menlo Park, CA (US);
Wenlang Fu, Rahway, NJ (US);
Denise M. Kenski, San Francisco, CA (US);
Ning Qi, Rahway, NJ (US);
Assignee:
SIRNA THERAPEUTICS, INC., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C07H 21/02 (2006.01); C12N 15/113 (2010.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/32 (2013.01); C12N 2310/322 (2013.01); C12N 2310/331 (2013.01); C12N 2320/11 (2013.01); C12N 2320/51 (2013.01);
Abstract
It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.