The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 06, 2016

Filed:

Dec. 20, 2014
Applicant:

The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Gladstone, San Francisco, CA (US);

Inventors:

Saiyong Zhu, San Francisco, CA (US);

Sheng Ding, Orinda, CA (US);

Holger Willenbring, San Francisco, CA (US);

Milad Rezvani, San Francisco, CA (US);

Jack Harbell, San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/407 (2015.01); A61K 31/506 (2006.01); A61K 31/661 (2006.01); A61K 31/19 (2006.01); A61K 31/135 (2006.01); A61K 31/405 (2006.01); A61K 31/4709 (2006.01); A61K 31/573 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12N 5/067 (2013.01); A61K 31/135 (2013.01); A61K 31/19 (2013.01); A61K 31/405 (2013.01); A61K 31/4709 (2013.01); A61K 31/506 (2013.01); A61K 31/573 (2013.01); A61K 31/661 (2013.01); A61K 35/407 (2013.01); A61K 45/06 (2013.01); C12N 2501/065 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/119 (2013.01); C12N 2501/12 (2013.01); C12N 2501/15 (2013.01); C12N 2501/16 (2013.01); C12N 2501/237 (2013.01); C12N 2501/415 (2013.01); C12N 2506/02 (2013.01); C12N 2506/1307 (2013.01); C12N 2506/45 (2013.01);
Abstract

Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.


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