The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
Dec. 14, 2015
Applicant:
Adaptimmune Limited, Abingdon, GB;
Inventors:
Jonathan Michael Boulter, Abingdon, GB;
Bent Karsten Jakobsen, Abingdon, GB;
Yi Li, Abingdon, GB;
Peter Eamon Molloy, Abingdon, GB;
Steven Mark Dunn, Abingdon, GB;
Assignee:
ADAPTIMMUNE LIMITED, Abingdon, GB;
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 17/00 (2006.01); C07K 14/725 (2006.01); A61K 35/12 (2015.01); C07K 14/705 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 35/12 (2013.01); C07K 14/705 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a Kfor the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (k) of 1×10Sor slower.