The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
Mar. 05, 2015
Applicant:
Cedars-sinai Medical Center, Los Angeles, CA (US);
Inventors:
Moshe Arditi, Encino, CA (US);
Pearl S. Gray, Los Angeles, CA (US);
Assignee:
Cedars-Sinai Medical Center, Los Angeles, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); A61K 38/17 (2006.01); C07K 14/705 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); A61K 38/177 (2013.01); A61K 38/16 (2013.01); C07K 14/435 (2013.01); C07K 14/47 (2013.01);
Abstract
The present invention is based on a novel, alternatively spliced human isoform of MD-2 (MD-2s). In addition, the present invention relates to modified MD-2 proteins, wherein one or more tyrosine residues have been mutated to phenylalanine. In various embodiments, the invention relates to methods and kits for preventing, reducing the likelihood of developing and/or treating various conditions using MD-2s. The invention also describes methods of determining the risk of a subject to various conditions.