The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 06, 2016

Filed:

Feb. 18, 2013
Applicant:

Fundacao Butantan, Sao Paulo, SP, BR;

Inventors:
Assignee:

Fundação Butantan, Avenida Vital, BR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/04 (2006.01); A61K 49/00 (2006.01); A61K 39/02 (2006.01); C07K 14/245 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/245 (2013.01); A61K 39/04 (2013.01); A61K 2039/523 (2013.01); A61K 2039/55516 (2013.01);
Abstract

The present invention relates to recombinantstrain that encodes the mutatedLT heat-labile toxin or the A subunit of the mutatedLT heat-labile toxin. The present invention also relates to strains ofthat encode the LT heat-labile toxin or the A subunit of the LT heat-labile toxin ofmutated in position 63. Specifically, the present invention relates to strains ofthat encode the LT heat-labile toxin or the A subunit of the LT heat-labile toxin ofmutated in position 63 from serine to lysine. The present invention also provides immunogenic compositions that comprise the strains of the present invention. The present invention further provides for the use of said strains and immunological compositions in the production of a vaccine for preventing tuberculosis and infections caused by. Lastly, the present invention relates to methods for preventing or treating tuberculosis in animals.


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