The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
Dec. 12, 2011
Applicant:
Susan C. Bock, Salt Lake City, UT (US);
Inventor:
Susan C. Bock, Salt Lake City, UT (US);
Assignee:
UNIVERSITY OF UTAH RESEARCH FOUNDATION, Salt Lake City, UT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/005 (2006.01); A61K 39/145 (2006.01); A61K 39/12 (2006.01); A61K 39/00 (2006.01); A61K 35/76 (2015.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/58 (2013.01); C12N 2760/16034 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01);
Abstract
A method of identification and elimination of immunodominant epitopes to elicit a response to secondary epitopes, especially conserved structures, is described, and applied to influenza haemagglutinin (HA). Identification of the primary epitopes in (HA), and replacement of amino acids having high LODrps with corresponding low LODrps amino acids produces an HA molecule which induces antibody responses to conserved HA residues. Modified HA molecules induce a broadly neutralizing vaccine.