The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
Dec. 21, 2012
Applicant:
Knopp Biosciences Llc, Pittsburgh, PA (US);
Inventors:
Weirong Chen, Waltham, MA (US);
Michael Humora, Cranbury, NJ (US);
Daw-long Albert Kwok, Gillette, NJ (US);
William F. Kiesman, Wayland, MA (US);
Erwin Ayandra Irdam, Melrose, MA (US);
Assignee:
Knopp Biosciences, LLP, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 277/82 (2006.01);
U.S. Cl.
CPC ...
C07D 277/82 (2013.01);
Abstract
The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.