The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
Feb. 17, 2012
Francesco Della Valle, Milan, IT;
Maria Federica Della Valle, Milan, IT;
Gabriele Marcolongo, Milan, IT;
Vincenzo Di Marzo, Milan, IT;
Salvatore Cuzzocrea, Milan, IT;
Francesco Della Valle, Milan, IT;
Maria Federica Della Valle, Milan, IT;
Gabriele Marcolongo, Milan, IT;
Vincenzo Di Marzo, Milan, IT;
Salvatore Cuzzocrea, Milan, IT;
Epitech Group S.r.l., Milan, IT;
Abstract
The present invention regards compositions and methods for the modulation of amidases capable of hydrolyzing N-acylethanolamines useable in the therapy of inflammatory diseases. In particular, the present invention regards a compound of general formula (I): enantiomers, diastereoisomers, racemes and mixtures, polymorphs, salts, solvates thereof, wherein: (a) R is a linear alkyl radical having 13 to 19 carbon atoms or alkenyl radical having 13 to 19 carbon atoms carrying a double bond; (b) X is 0 or S; (c) Y is a 2 or 3 carbon atom alkylene residue, optionally substituted with one or two groups equal or different from each other and selected from among the group consisting of: —CH, —CHOH, —COOCH, —COOH. Y may preferably be: —CH—CH—, —CH—CH—CH—, CH(CH)—CH—, —CH—CH(CH)—, —CH—C(CH)—, —CH—CH(CHOH)—, —CH—C((CHOH))—, —CH═CH—, —CH—CH(COOCH)—, —CH—CH(COOH)—, for use as a medicine.