The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
Jul. 10, 2013
Applicant:
Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US);
Inventors:
Anand Natrajan, Manchester, NH (US);
David Wen, Northborough, MA (US);
Assignee:
SIEMENS HEALTHCARE DIAGNOSTICS INC., Tarrytown, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 219/04 (2006.01);
U.S. Cl.
CPC ...
C07D 219/04 (2013.01);
Abstract
A method is provided for N-alkylation of acridine compounds by reduction of acridines to corresponding acridans to improve the reactivity of the acridine nitrogen, and subsequent N-alkylation of the acridans in ionic liquid solvents to provide the corresponding acridinium compounds in high yield. This inventive process improves chemical conversion, and does not require the use of highly toxic alkylating agents, such as 1,3-propane sultone.