The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
May. 22, 2014
Applicants:
Christopher W. Ward, Baltimore, MD (US);
Ramzi Khairallah, Chicago, IL (US);
Inventors:
Christopher W. Ward, Baltimore, MD (US);
Ramzi Khairallah, Chicago, IL (US);
Assignee:
University of Maryland, Baltimore, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61K 31/165 (2006.01); A61K 31/12 (2006.01); A61K 31/4178 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1767 (2013.01); A61K 31/12 (2013.01); A61K 31/165 (2013.01); A61K 31/4178 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention provides methods for improving muscular function or treating a muscular disorder in an individual by administering to the individual a pharmacologically effective amount of a compound that inhibits microtubule-dependent NADPH Oxidase 2 reactive oxygen species signaling production. In addition compounds that block sarcolemmal Cachannel activation and/or renin-angiotensin signaling may be administered with the inhibitor of microtubule-dependent NADPH Oxidase 2 reactive oxygen species signaling production.