The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2016
Filed:
Jul. 03, 2013
Applicants:
Basilea Pharmaceutica Ag, Basel, CH;
Universität Basel, Basel, CH;
Inventors:
Assignee:
BASILEA PHARMACEUTICA AG, Bassel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/18 (2006.01); A61K 31/475 (2006.01); C07D 459/00 (2006.01); A61K 31/155 (2006.01); A61K 31/365 (2006.01); A61K 45/06 (2006.01); C07D 471/14 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 31/475 (2013.01); A61K 31/155 (2013.01); A61K 31/365 (2013.01); A61K 45/06 (2013.01); C07D 459/00 (2013.01); C07D 471/14 (2013.01); G01N 33/5011 (2013.01); G01N 2458/00 (2013.01); G01N 2500/10 (2013.01);
Abstract
The invention relates to novel Rauwolfia alkaloid derivatives of formula (I) combinations of Rauwolfia alkaloid derivatives and a mitochondrial inhibitor, e.g. metformin, and the use of Rauwolfia alkaloid derivatives in combination with mitochondrial inhibitor for the treatment of cancer and for achieving clinical immunosuppression. The invention also relates to a fluorescence-based method for predicting the sensitivity of a cancer cell towards a compound of formula (I).