The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2016
Filed:
Feb. 22, 2013
Oregon State Board of Higher Education on Behalf of Portland State University, Portland, OR (US);
Robert M. Strongin, Portland, OR (US);
Yixing Guo, Marlborough, MA (US);
Lovemore Hakuna, Portland, OR (US);
Mark Allen Lowry, Portland, OR (US);
Jorge Omar Escobedo Córdova, Portland, OR (US);
Portland State University, Portland, OR (US);
Abstract
Probes for selectively detecting compounds comprising a thiol group and an amino group ('thiols') are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as '' is a single or double bond; R, R-Rand Rindependently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; Ris an α,β-unsaturated aliphatic ester; Ris oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or Rand Rtogether form a cycloalkyl or aryl ring; Xis CH, S, NH, O, Se, Si(CH), Ge(CH), Sn(CH), or C(CH); and Xis CH, CH, N, NH, or CRwhere Ris aryl.