The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2016
Filed:
Dec. 26, 2011
Humberto Lamdan Ordas, Artemisa, CU;
Jorge Victor Gavilondo Cowley, La Habana, CU;
Marta Ayala Avila, La Habana, CU;
Yasmiana Muñoz Pozo, La Habana, CU;
Amaury Pupo Meriño, La Habana, CU;
Gertrudis Rojas Dorantes, La Habana, CU;
Lincidio Perez Sanchez, La Habana, CU;
Humberto Lamdan Ordas, Artemisa, CU;
Jorge Victor Gavilondo Cowley, La Habana, CU;
Marta Ayala Avila, La Habana, CU;
Yasmiana Muñoz Pozo, La Habana, CU;
Amaury Pupo Meriño, La Habana, CU;
Gertrudis Rojas Dorantes, La Habana, CU;
Lincidio Perez Sanchez, La Habana, CU;
Centro de Ingenieria Genetica y Biotechnologia, Havana, CU;
Biorec S.A., Montevideo, UY;
Abstract
The present invention reveals human recombinant antibodies that recognize the human Vascular Endothelium Growth Factor A (VEGF-A), block its interaction with the VEGFR2 receptor, and interfere with its proliferative effect in vitro and pro-angiogenic effect in vivo. The antibodies identify an epitope on human VEGF-A different from any other previously reported, and were obtained by combining one immunoglobulin light chain variable region with other three heavy chain ones. The antibodies were obtained by human immunoglobulin variable region mutagenesis, and can be employed for the immunotherapy of pathological entities associated with an increase in vasculature, such as age-related macular degeneration, cancer, and others.