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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9505816 B1

PDFFull Text
Date of Patent:
Nov. 29, 2016

Filed:

May. 15, 2015

Methods and compositions for specific modulation of mcl-1

Applicant:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

Loren D. Walensky, Newton Centre, MA (US);

Michelle L. Stewart, Brookline, MA (US);

Assignee:

Dana-Farber Cancer Institute, Inc., Boston, MA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Marcela M Cordero Garcia

Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/47 (2006.01); A61K 31/00 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); A61K 38/08 (2006.01); A61K 38/10 (2006.01); A61K 38/17 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); A61K 31/00 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 38/1709 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 14/4747 (2013.01); G01N 33/5011 (2013.01); G01N 33/57484 (2013.01); A61K 38/00 (2013.01);
Abstract

A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.

Find Patent Forward Citations

Walensky, Loren. (2016). Methods and compositions for specific modulation of mcl-1 (U.S. Patent No. 9505816). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9505816

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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