The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2016
Filed:
Sep. 21, 2012
Instytut Biochemii I Biofizyki Pan, Warsaw, PL;
Agnieszka Sirko, Warsaw, PL;
Anna Góra-Sochacka, Warsaw, PL;
Włodzimierz Zagórski-Ostoja, Warsaw, PL;
Anna Stachyra, Warsaw, PL;
Róza Sawicka, Makó Mazowiecki, PL;
Bogusław Szewczyk, Gdańsk, PL;
Beata Gromadzka, Gdańsk, PL;
Violetta Sączyńska, Warsaw, PL;
Katarzyna Florys, Iwaniska, PL;
Zenon Minta, Pulawy, PL;
Krzysztof Śmietanka, Puławy, PL;
INSTYTUT BIOCHEMII I BIOFIZYKI PAN, Warsaw, PL;
Abstract
The object of the invention is a DNA vaccine, method of inducing the immune response, antibodies specifically recognizing the haemagglutinin H5 of an influenza virus and application of the DNA vaccine. According to the invention, one or two-fold immunization of hens with DNA vaccine containing a cDNA encoding the modified H5 haemagglutinin HA protein, i.e. with the deletion of the cleavage site between HA subunits (this provides for greater safety of the vaccines). Moreover, the encoding region of the HA is modified in such a way that protein production in the bird cells should achieve maximal yield. The main modification is codon optimization for the hens and deletion of the site of proteolytic cleavage between subunits HA1 and HA2.