The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2016
Filed:
Jun. 21, 2013
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Catherine McLellan, Somerville, MA (US);
Ralph Mazitschek, Belmont, MA (US);
Luke Whitesell, Somerville, MA (US);
Susan L. Lindquist, Cambridge, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention provides compounds of Formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting fungal or parasitic growth. The compounds are useful as inhibitors of glycosylphosphatidylinositol (GPI)-anchor biosynthesis, in particular, as inhibitors of fungal Gwt1 activity. The present invention further provides methods of using the compounds described herein for treating fungal or parasitic infections. The compounds can also be used as biological probes to study the effects of inhibiting Gwt1 activity.