The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2016
Filed:
Feb. 03, 2012
Applicant:
Dale L. Boger, La Jolla, CA (US);
Inventor:
Dale L. Boger, La Jolla, CA (US);
Assignee:
The Scripps Research Institute, La Jolla, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 413/04 (2006.01); A61K 31/421 (2006.01); A61K 45/06 (2006.01); C07D 271/10 (2006.01); A61K 31/4439 (2006.01); A61K 31/4245 (2006.01); C07D 263/32 (2006.01); C07D 263/34 (2006.01);
U.S. Cl.
CPC ...
A61K 31/421 (2013.01); A61K 31/4245 (2013.01); A61K 31/4439 (2013.01); A61K 45/06 (2013.01); C07D 263/32 (2013.01); C07D 263/34 (2013.01); C07D 271/10 (2013.01); C07D 413/04 (2013.01);
Abstract
Compounds are disclosed that are effective in inhibition of fatty acid amide hydrolase, an enzyme responsible for catabolism of endogenous cannabinoids such as anandamide. The compounds are useful as analgesic compounds and as sleep-inducing compounds, that can be orally administered, and that can have a relatively long duration of effect. Methods of preparation of the compounds are also provided. The compounds are conformationally constrained analogs of heterocyclylketones such as oxazolylketones.