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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9504669 B1

PDFFull Text
Date of Patent:
Nov. 29, 2016

Filed:

Aug. 05, 2015

Spliceostatin analogs and methods for their preparation

Applicant:

Pfizer Inc., New York, NY (US);

Inventors:

Chakrapani Subramanyam, South Glastonbury, CT (US);

Frank Erich Koehn, Mystic, CT (US);

Kenneth John Dirico, Gales Ferry, CT (US);

Alessandra S. Eustaquio, Old Saybrook, CT (US);

Michael Eric Green, Boston, MA (US);

Haiyin He, Mahwah, NJ (US);

Min He, North Potomac, MD (US);

Christopher John O'Donnell, Mystic, CT (US);

Sujiet Puthenveetil, North Attleboro, MA (US);

Anokha Ratnayake, Mystic, CT (US);

Jesse Alexander Teske, Westerly, RI (US);

Hui Yu Yang, Newton, MA (US);

Assignee:

Pfizer Inc., New York, NY (US);

Attorney:

David Rubin

Primary Examiner:

Jeanette Lieb

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 31/351 (2006.01); C07D 309/10 (2006.01); C07D 405/12 (2006.01); C07D 493/20 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); C07D 309/14 (2006.01); C07D 405/14 (2006.01); C07D 493/10 (2006.01); A61K 31/397 (2006.01); A61K 31/453 (2006.01); A61K 31/496 (2006.01); A61K 31/501 (2006.01);
U.S. Cl.
CPC ...
A61K 31/351 (2013.01); A61K 31/397 (2013.01); A61K 31/453 (2013.01); A61K 31/496 (2013.01); A61K 31/501 (2013.01); A61K 45/06 (2013.01); A61K 47/48384 (2013.01); A61K 47/48584 (2013.01); A61K 47/48638 (2013.01); A61K 47/48715 (2013.01); C07D 309/10 (2013.01); C07D 309/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 493/10 (2013.01); C07D 493/20 (2013.01);
Abstract

The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.

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