The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2016
Filed:
Jul. 18, 2013
Hoau-yan Wang, Philadelphia, PA (US);
Lindsay Burns Barbier, Austin, TX (US);
Hoau-Yan Wang, Philadelphia, PA (US);
Lindsay Burns Barbier, Austin, TX (US);
Pain Therapeutics, Inc., Austin, TX (US);
Abstract
An assay for Alzheimer's disease pathology (AD) in a living patient is disclosed wherein an amount of α7nAChR-FLNA, TLR4-FLNA and/or α7nAChR-Aβcomplex present as a protein-protein complex in a sample is determined and compared to the amount in a standard sample from a person free of AD pathology. Use of one or more of those ratios provides an assay predictive of prognosis for treatment with a medicament in which the amount of an above protein complex is determined and compared to an amount determined in the presence of a medicament that binds to a FLNA pentapeptide and contains at least four of the six pharmacophores of FIGS.-. An amount of protein complex determined in the presence of the medicament less than the first determined amount indicates a favorable treatment prognosis.