The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2016
Filed:
Jul. 02, 2014
Applicant:
Research Development Foundation, Carson City, NV (US);
Inventors:
Michael G. Rosenblum, Sugar Land, TX (US);
Khalid Amanali Mohamedali, Houston, TX (US);
Lawrence H. Cheung, Houston, TX (US);
Assignee:
Research Development Foundation, Carson City, NV (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/50 (2006.01); C12N 15/62 (2006.01); A61K 38/00 (2006.01); C12N 9/64 (2006.01); C07K 14/47 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6467 (2013.01); C07K 14/001 (2013.01); C07K 14/4747 (2013.01); C07K 16/00 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); C12N 9/6424 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/03 (2013.01); C07K 2319/10 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/50 (2013.01); C07K 2319/55 (2013.01);
Abstract
Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.