The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 22, 2016

Filed:

Oct. 27, 2015
Applicant:

Abbvie Inc., North Chicago, IL (US);

Inventors:

Kartik Subramanian, Northborough, MA (US);

Mayda Perez Thiele, Vega Alta, PR (US);

Xiaobei Zeng, Carolina, PR (US);

Chee Furng Wong, Singapore, SG;

Zehra Kaymakcalan, Westborough, MA (US);

Ying Jing, Wellesley, MA (US);

Christopher M. Chumsae, North Andover, MA (US);

Assignee:

ABBVIE INC., Chicago, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/08 (2006.01); C07K 16/24 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/241 (2013.01); C12P 21/005 (2013.01); C07K 2317/14 (2013.01); C07K 2317/565 (2013.01);
Abstract

The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.


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