The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 22, 2016

Filed:

Jul. 01, 2011
Applicants:

Shaowei LI, Xiamen, CN;

Xiaobing MO, Xiamen, CN;

Minxi Wei, Xiamen, CN;

Huirong Pan, Xiamen, CN;

Jun Zhang, Xiamen, CN;

Ningshao Xia, Xiamen, CN;

Inventors:

Shaowei Li, Xiamen, CN;

Xiaobing Mo, Xiamen, CN;

Minxi Wei, Xiamen, CN;

Huirong Pan, Xiamen, CN;

Jun Zhang, Xiamen, CN;

Ningshao Xia, Xiamen, CN;

Assignees:

XIAMEN UNIVERSITY, Xiamen, Fujian Province, CN;

XIAMEN INNOVAX BIOTECH CO., LTD., Haicang, Xiamen, Fujian, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C07K 14/025 (2006.01); C07K 14/005 (2006.01); A61K 39/00 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
C07K 14/025 (2013.01); A61K 39/0011 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); C12P 21/02 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/585 (2013.01); C12N 2710/20022 (2013.01); C12N 2710/20023 (2013.01); C12N 2710/20034 (2013.01); C12N 2710/20051 (2013.01);
Abstract

Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at the N-terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein, a virus-like particle (VLP) comprising the protein, and a method of preparing the protein and the VLP using anexpression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and a disease caused by HPV52 infection, such as cervical cancer.


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