logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9499502 B1

PDFFull Text
Date of Patent:
Nov. 22, 2016

Filed:

Apr. 12, 2012

5-substituted iminothiazines and their mono- and dioxides as bace inhibitors, compositions, and their use

Applicants:

Wen-lian Wu, Edison, NJ (US);

Duane A. Burnett, Bernardsville, NJ (US);

Andrew W. Stamford, Chatham, NJ (US);

Jared N. Cumming, Garwood, NJ (US);

Chad E. Bennett, Metuchen, NJ (US);

Eric J. Gilbert, Scotch Plains, NJ (US);

Jack D. Scott, Scotch Plains, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Xuanjia Peng, Shanghai, CN;

Inventors:

Wen-Lian Wu, Edison, NJ (US);

Duane A. Burnett, Bernardsville, NJ (US);

Andrew W. Stamford, Chatham, NJ (US);

Jared N. Cumming, Garwood, NJ (US);

Chad E. Bennett, Metuchen, NJ (US);

Eric J. Gilbert, Scotch Plains, NJ (US);

Jack D. Scott, Scotch Plains, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Xuanjia Peng, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Keith D. MacMillan

John C. Todaro

Primary Examiner:

San-Ming Hui

Assistant Examiner:

Andrew Lee

Int. Cl.
CPC ...
C07D 279/12 (2006.01); A61K 45/06 (2006.01); C07D 417/04 (2006.01); A61K 31/541 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61K 31/54 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 279/12 (2013.01); A61K 31/54 (2013.01); A61K 31/541 (2013.01); A61K 45/06 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The present invention discloses certain iminothiazine compounds and mono- and dioxides thereof, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomers and said stereoisomers, wherein each of variables shown in the formula are as defined herein. The compounds of the invention may be useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and uses, including Alzheimer's disease, are also disclosed.

Find Patent Forward Citations

Loading…