The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2016
Filed:
Mar. 13, 2014
Paul A. Barsanti, Pleasant Hill, CA (US);
Sylvie Chamoin, St. Louis, FR;
Lionel Doumampouom-metoul, Rosenau, FR;
Stephanie Guerro-lagasse, Basel, CH;
Robert Martin Grotzfeld, Ettingen, CH;
Alexei Karpov, Basel, CH;
Marc Lafrance, Basel, CH;
Cristina Montserrat Nieto-oberhuber, Basel, CH;
Grazia Piizzi, Hegenheim, FR;
Paul A. Barsanti, Pleasant Hill, CA (US);
Sylvie Chamoin, St. Louis, FR;
Lionel Doumampouom-Metoul, Rosenau, FR;
Stephanie Guerro-Lagasse, Basel, CH;
Robert Martin Grotzfeld, Ettingen, CH;
Alexei Karpov, Basel, CH;
Marc Lafrance, Basel, CH;
Cristina Montserrat Nieto-Oberhuber, Basel, CH;
Grazia Piizzi, Hegenheim, FR;
NOVARTIS AG, Basel, CH;
Abstract
Disclosed herein are immunoconjugates comprising an inhibitor of Eg5 linked to an antigen binding moiety such as an antibody, that are useful for treating cell proliferative disorders. Also disclosed are novel inhibitors of Eg5 that can be used either alone or as part of an immunoconjugate to treat cell proliferation disorders. The Eg5 inhibitors include compounds of this formula as described herein: The invention further provides pharmaceutical compositions comprising these compounds and immunoconjugates, and compositions comprising the immunoconjugates or compounds with a therapeutic co-agent, and methods to use these compounds, conjugates and compositions for treating cell proliferation disorders.