The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 22, 2016

Filed:

Jul. 03, 2014
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Washington, DC (US);

Inventors:

Jau-Shyong Hong, Durham, NC (US);

Liya Qin, Durham, NC (US);

Guorong Li, Chapel Hill, NC (US);

Michelle Block, Holly Springs, NC (US);

Wei Zhang, Dalian, CN;

Po-See Chen, Taipei, TW;

Giia-Shuen Peng, Taipei, TW;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 38/08 (2006.01); A61K 38/06 (2006.01); A61K 38/33 (2006.01); A61K 31/19 (2006.01); A61K 31/46 (2006.01);
U.S. Cl.
CPC ...
A61K 38/08 (2013.01); A61K 31/19 (2013.01); A61K 31/46 (2013.01); A61K 31/485 (2013.01); A61K 38/06 (2013.01); A61K 38/33 (2013.01);
Abstract

The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related condition, and inhibiting NADPH oxidase, that includes contacting or administering an effective amount of at least one compound of the invention that include: valproic acid, sodium butyrate, and salts thereof; opioid peptides; a peptide comprising the tripeptide GGF; and morphinans, such as naloxone, naltrexone, 3-hydroxy-morphinan and dextromethorphan.


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