The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Jan. 28, 2013
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Universite Paris Diderot (Paris Vii), Paris, FR;
Universite DE Versailles Saint-quentin-en-yvelines, Versailles, FR;
Universite Paris Descartes, Paris, FR;
Assistance Publique-hopitaux DE Paris, Paris, FR;
Pierre-Emmanuel Rautou, Paris, FR;
Chantal Boulanger, Paris, FR;
Dominique-Charles Valla, Paris, FR;
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris, FR;
UNIVERSITE PARIS DIDEROT (PARIS VII), Paris, FR;
UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES, Versailles, FR;
UNIVERSITE PARIS DESCARTES, Paris, FR;
ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, Paris, FR;
Abstract
The present invention relates to a method for determining whether a patient with cirrhosis is at risk of having clinically significant portal hypertension comprising the steps consisting of i) quantifying the levels of leuko-endothelial (CD31+/41−), pan-leukocyte (CD11a+), lymphocyte (CD4+), erythrocyte (CD235a+) and hepatocyte-derived (cytokeratin-18+) microparticles in a blood sample obtained from the patient and ii) comparing said levels with predetermined reference values wherein a difference between the levels quantified at step i) and the predetermined reference values is indicative whether the patient is at risk of having clinically significant portal hypertension.