The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 15, 2016

Filed:

Nov. 21, 2012
Applicants:

The Royal Institution for the Advancement of Learning/mcgill University, Montreal, CA;

German Cancer Research Center (Dkfz), Heidelberg, DE;

Universitatsklinikum Heidelberg, Heidelberg, DE;

Inventors:

Nada Jabado, Montreal, CA;

Stefan M. Pfister, Heidelberg, DE;

Christoph Plass, Schriesheim-Altenbach, DE;

Andrey Korshunov, Heidelberg, DE;

Hendrik Witt, Heidelberg, DE;

Dominik Sturm, Heidelberg, DE;

David Jones, Heidelberg, DE;

Peter Lichter, Gaiberg, DE;

Elke Pfaff, Heidelberg, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); G01N 33/574 (2006.01); C07K 14/47 (2006.01); G01N 33/68 (2006.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57496 (2013.01); C07K 14/47 (2013.01); C07K 16/18 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57407 (2013.01); G01N 33/6875 (2013.01); A61K 38/00 (2013.01); C07K 2317/34 (2013.01); G01N 2500/00 (2013.01); G01N 2800/50 (2013.01); G01N 2800/56 (2013.01);
Abstract

The present application shows the relationship between variations in the amino acid sequence of histone proteins, more specifically the H3.3 protein, and proliferation-associated disorders. Herewith provided are predictive methods, commercial packages, therapeutic methods and screening methods based on this relationship.


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