The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Feb. 09, 2012
Applicant:
Wei Huang, Foster City, CA (US);
Inventor:
Wei Huang, Foster City, CA (US);
Assignee:
MONOGRAM BIOSCIENCES, INC., San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/70 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/703 (2013.01); C12N 2740/16111 (2013.01);
Abstract
The invention provides a method for determining whether a human immunodeficiency virus is likely to be have enhanced ability to enter a cell expressing CD4 and CXCR4 relative to a reference HIV. In certain aspects, the methods comprise detecting one or more amino acids in an envelope protein of the HIV associated with enhanced ability to enter CD4- and CXCR4-expressing cells and determining that the HIV's ability to enter such cells is enhanced relative to a reference HIV, e.g., an HIV that does not comprise such amino acid(s).