The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Jan. 05, 2009
Elena V. Getmanova, Lexington, MA (US);
Alexander Kovtun, Stow, MA (US);
Lin Sun, West Roxbury, MA (US);
Edward Fritsch, Concord, MA (US);
Brian Seed, Boston, MA (US);
Elena V. Getmanova, Lexington, MA (US);
Alexander Kovtun, Stow, MA (US);
Lin Sun, West Roxbury, MA (US);
Edward Fritsch, Concord, MA (US);
Brian Seed, Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Disclosed herein are methods and compositions related to engineered fragments of the human transglutaminase-related protein family, described herein as engineered transglutaminase barrel proteins (ETBPs), that have utility as high affinity, high selectivity target-binding proteins offering advantages as antibody equivalents for therapeutic, analytical, manufacturing and research purposes. ETBPs differ from naturally occurring human transglutaminase fragments by the addition, deletion, replacement and/or substitution of the naturally occurring amino acid sequence. ETBPs can be easily expressed in prokaryotic cells and in many cases can be purified by a simple solubilization and precipitation method.