The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Oct. 02, 2009
Peter Armstrong Thompson, Bellevue, WA (US);
Peter Robert Baum, Seattle, WA (US);
Philip Tan, Edmonds, WA (US);
John W. Blankenship, Seattle, WA (US);
Sateesh Kumar Natarajan, Redmond, WA (US);
Peter Armstrong Thompson, Bellevue, WA (US);
Peter Robert Baum, Seattle, WA (US);
Philip Tan, Edmonds, WA (US);
John W. Blankenship, Seattle, WA (US);
Sateesh Kumar Natarajan, Redmond, WA (US);
APTEVO RESEARCH AND DEVELOPMENT LLC, Seattle, WA (US);
Abstract
This disclosure provides a multi-specific fusion protein composed of a CD86 antagonist binding domain and another binding domain that is an IL-10 agonist, an HLA-G agonist, an HGF agonist, an IL-35 agonist, a PD-1 agonist, a BTLA agonist, a LIGHT antagonist, a GITRL antagonist or a CD40 antagonist. The multi-specific fusion protein may also include an intervening domain that separates the other domains. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.